This study, presented by Dr. Mariam Eskander at the 2025 ASCO Annual Meeting, explores how living in a food desert impacts breast cancer clinical trial enrollment, compounded by transportation and distance challenges. Analyzing data from over 1.3 million breast cancer patients treated between 2022 and 2024, researchers found that residents of food deserts had lower clinical trial participation rates. Key factors associated with reduced enrollment include living in both food and clinical trial deserts (areas over 2 hours from trial sites), limited transportation access, and having Medicaid insurance. Patients treated at academic hospitals were more likely to enroll. The study highlights a "double desert" effect, where combined barriers significantly reduce trial participation, suggesting interventions such as patient navigation and expanded trial access could improve enrollment in underserved communities.