In a recent presentation co-sponsored by the Faculty of Arts and Sciences’ Division of Science and Harvard Library, Neal Baer, a medical professional and screenwriter, explored the ethical implications of CRISPR technology alongside Rebecca Weintraub Brendel, director of Harvard Medical School’s Center for Bioethics. The discussion centered on whether humanity has the right or responsibility to alter genetic differences using cutting-edge gene-editing tools. This talk, titled “The Promise and Peril of CRISPR,” delved into complex moral quandaries surrounding genetic modification, particularly its application in treating diseases like sickle cell anemia.
Neal Baer recounted his early experiences as a physician treating children with sickle cell anemia, emphasizing the suffering he witnessed and the limited treatment options available at the time. Today, advancements in CRISPR allow for the potential cure of such conditions through somatic gene editing. However, the ability to edit germline genes raises significant ethical questions about who decides which traits should be modified and the broader societal implications.
Baer highlighted concerns regarding fairness and health equity, noting that while CRISPR offers revolutionary cures, they come at exorbitant costs—approximately $2.2 million per patient for the sickle cell treatment. With global disparities in access to healthcare, this raises issues of justice and affordability. Furthermore, Brendel emphasized the cautionary nature of rapid innovation, arguing that ethical considerations must accompany scientific progress.
Another dimension of the debate involves parental rights and choices. For instance, should parents have the authority to genetically modify their offspring? This question becomes even more complex when considering scenarios where modifications might conflict with personal identities, such as altering traits associated with deafness or albinism. Contributions from experts like Carol Padden, who identifies her deafness as part of human variation rather than pathology, underscore the nuanced perspectives involved.
Baer also addressed concerns about oversight and unintended consequences. He questioned how regulatory frameworks can effectively monitor CRISPR applications globally, citing examples from countries like Russia and China. Additionally, he warned against underestimating the complexity of gene interactions, pointing out that seemingly straightforward edits could disrupt other critical biological processes.
Ultimately, the dialogue between Baer and Brendel illuminated the intricate balance required in harnessing CRISPR's potential while safeguarding ethical standards. As science advances, it becomes imperative to consider not only what we can achieve but also what we should pursue, ensuring equitable access and respect for diverse human experiences.
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